GRADUATE PHARMACY APTITUDE

GRADUATE PHARMACY APTITUDE

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1/22/2020 12:52:44 AM
DRUGS OF CHOICE 

1. Paracetamol poisoning- acetyl cysteine
 2. Acute bronchial asthma: - salbutamol
 3. Acute gout: - NSAIDS
 4. Acute hyperkalemia: - calcium gluconate
 5. Severe DIGITALIS toxicity: - DIGIBIND
 6. Acute migraine: - sumatriptan
 7. Cheese reaction: - phentolamine
 8. Atropine poisoning: - physostigmine
 9. Cyanide poisoning: - amyl nitrite
 10. Benzodiazepine poisoning: - flumazenil
 11. Cholera: - tetracycline
 12. KALA-AZAR:- lipozomal amphotericin- B 13. Iron poisoning: - desferrioxamine
  14. MRSA: - vancomycin
 15. VRSA: - LINEZOLID 
16. Warfarin overdose: - vitamin-K (NIPER-2009) 
17. OCD: - fluoxetine 18. Alcohol poisoning: - fomepizole 
19. Epilepsy in pregnency: - Phenobarbitone 20. Anaphylactic shock: - Adrenaline
 21. MRSA Infection-Vancomycin
 22. Malaria in Pregnancy-Chloroquine
 23. Whooping Cough or Pertussis- Erythromycin
 24. Kawasaki disease-IV Ig
 25. Warfarin Overdose-Vit-K
 26. Heparin Overdose-Protamine
 27. Hairy Cell Leukemia-Cladirabine
 28. Multiple Myeloma- Melphalan
 29. CML-Imatinib
 30. Wegner's granulomatosis-Cyclophosphamide
 31. HOCM- Propranolol
 32. Delirium Tremens-Diazepam
 33. Drug Induced Parkinsonism-Benzhexol
 34. Diacumarol Poisoning-Vit-K
 35. Type-1 Lepra Reaction-Steroids
 36. Type- 2 Lepra Reaction-Thalidomide
 37. Allergic Contect Dermatitis-Steroids
 38. PSVT- 1st-Adenosine, 2nd-Verapamil, 3rd-Digoxin
 39. Z-E Syndrome- Proton Pump Inhibitor
 40. Chancroid-Cotrimoxazole
 41. Dermatitis Herpetiformis-Dapsone
 42. Spastic Type of Cerebral Palsy-Diazepam 43. Herpis Simplex Keratitis-Trifluridine
 44. Herpes Simplex Orolabialis-Pancyclovir
 45. Neonatal Herpes Simplex-Acyclovir
 46. Pneumocystis carinii Pneumonia- Cotrimoxazole for Nodulo
  47. Cystic Acne- Retinoic acid
 48. Trigeminal Neuralgia-Carbamezapine
 49. Actinomycosis-Penicillin
1/22/2020 12:52:19 AM
CHEMICAL TEST FOR ANTHRAQUINONE GLYCOSIDES- 

 Brontrager’s test- This test is performed for the O-glycosides. Drug is dissolved in 1ml H2SO4 and mixture is boiled. Filter the solution, filterate is then mixed with chloroform. Chloroform layer mixed with ammonia gives rose pink color if O-glycosides are present. 

 Modified brontrager’s test- This test is performed for the investigation of C-glycosides. Drug is mixed with H2SO4 and FeCl3. The next procedure is same as for the O-glycosides in brontrager’s test.  

Hydroxy anthraquinones- Drug is mixed with Potassium Hydroxide. If hydroxy anthraquinones are present red color is present.
1/22/2020 12:46:11 AM
GENERAL CHEMICAL TESTS FOR ALKALOIDS:

 Alkaloids are tested by the following reagents. Each reagent or test has accuracy and specificity. 

i) Dragendroff’s reagent- This reagent is constituted of Potassium Bismuth Iodide (PBI). Alkaloids give reddish brown color with the dragendroff’s reagent.  

ii) Mayer’s reagent- This reagent is constituted of Potassium Mercuric Iodide (PMI). Alkaloids give cream color with the Mayer’s reagent. Remember M for Mayer M for Mercuric i

ii) Wagner’s reagent- This reagent is constituted of Iodine Potassium Iodide (IPI). Alkaloids give reddish brown precipitate with the Wagner’s reagent. 

iv) Hager’s reagent- This reagent is constitutes of Picric Acid. Alkaloids give yellow precipitate with the Hager’s reagent. v) Tannic acid- With tannic acid alkaloids give buff colored precipitate. 

vi) Picrolinic acid- Yellow colored precipitate are produced with picrolinic acid.
1/22/2020 12:44:29 AM
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1/21/2020 9:13:41 AM
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